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  • Title: Daxx-mediated transcriptional repression of MMP1 gene is reversed by SPOP.
    Author: La M, Kim K, Park J, Won J, Lee JH, Fu YM, Meadows GG, Joe CO.
    Journal: Biochem Biophys Res Commun; 2004 Jul 30; 320(3):760-5. PubMed ID: 15240113.
    Abstract:
    Daxx-mediated transcriptional repression was modulated by a speckled POZ domain protein SPOP which was first identified as an autoantigen from the serum of a scleroderma patient. This is the first report on the biochemical and functional interactions between Daxx and SPOP. The COOH-terminal region of Daxx interacts with the NH2-terminal region of SPOP. SPOP reversed the transcriptional repression mediated by Daxx which binds with ETS1 transcription factor to repress ETS1-responsive gene expression. Mutagenesis study suggests that the ability of SPOP to self-associate as well as its ability to bind with Daxx was important for the modulation of Daxx-mediated transcriptional repression.
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