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Title: Systemic mastocytosis associated with acute myeloid leukemia: case report and implications for disease pathogenesis. Author: Escribano L, Garca-Montero A, Núñez-López R, López-Jiménez J, Almeida J, Prados A, Orfao A. Journal: J Allergy Clin Immunol; 2004 Jul; 114(1):28-33. PubMed ID: 15241340. Abstract: Mastocytosis may be associated with clonal nonmast cell lineage hematologic diseases, including myelodysplastic syndromes, myeloproliferative disorders, and acute myeloid leukemia. Here we present a patient with the simultaneous diagnosis of mastocytosis and an acute myeloid leukemia, M2 subtype in the French-American-British classification, with t(8;21) carrying a population of immature mast cell precursors, and discuss this presentation in the context of a potential pathogenetic cellular link between this leukemia and mastocytosis.[Abstract] [Full Text] [Related] [New Search]