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  • Title: [The prostacyclin-thromboxane system and thrombocytic-vascular hemostasis in patients with ischemic heart disease in the preoperative period].
    Author: Abbakumov VV, Vinnitskiĭ LI, Kattakhanova RIu, Studennikova LN, Egorova IA, Smirnova LA.
    Journal: Anesteziol Reanimatol; 1992; (1):42-4. PubMed ID: 1524251.
    Abstract:
    Prostacyclin-thromboxane system (PTS) and platelet-vascular hemostasis have been studied in the preoperative period in 35 ischemic patients. A marked PTS disbalance with predominance of plasma thromboxane has been found. It has been established that in patients with postinfarction cardiosclerosis plasma prostacyclin content was significantly higher than in patients without myocardial infarction. The study of platelet function has demonstrated normal platelet aggregation rate and an increased level of beta-thromboglobulin in the blood of ischemic patients. Acetylsalicylic acid (250 mg/daily) was used for the correction of the disturbances observed, it reduced platelet aggregation, but had no effect on PTS and platelet release.
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