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  • Title: Warfarin and the vitamin K-dependent gamma-carboxylation system.
    Author: Wallin R, Hutson SM.
    Journal: Trends Mol Med; 2004 Jul; 10(7):299-302. PubMed ID: 15242675.
    Abstract:
    Insight into the molecular basis for genetic warfarin resistance has recently been accomplished by the identification of an 18-kDa protein of the endoplasmic reticulum that is targeted by the drug. When expressed in eukaryotic and insect cells, the protein reduces vitamin K1 2,3-epoxide in a warfarin-sensitive reaction. This finding strongly suggests that the protein is part of the vitamin K cycle, which is essential for the production of vitamin K-dependent proteins. Identification of the 18-kDa protein has aided the understanding of the vitamin K-dependent gamma-carboxylation system at the molecular level.
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