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  • Title: The abnormal spindle protein is required for germ cell mitosis and oocyte differentiation during Drosophila oogenesis.
    Author: Riparbelli MG, Massarelli C, Robbins LG, Callaini G.
    Journal: Exp Cell Res; 2004 Aug 01; 298(1):96-106. PubMed ID: 15242765.
    Abstract:
    In this study, we present evidence that the asp function is required in oogenesis for germline cell divisions as well as for cyst polarity and oocyte differentiation. Consistent with previously described roles in spindle organization during Drosophila meiosis and mitosis, asp mutation leads to severe defects in spindle microtubule organization within the germarium. The mitotic spindles of the mutant cystocytes are composed by wavy microtubules and have abnormal poles that often lack gamma-tubulin. The fusome structure is also compromised. In the absence of asp function, the cystocyte divisions fail resulting in egg chamber with fewer than 16 germ cells. Moreover, the microtubule network within the developing germline cysts may assemble incorrectly in turn affecting the microtubule based transport of the specific determinants that is required during mid-oogenesis for the oocyte differentiation program.
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