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  • Title: Trisomy 16 confined to chorionic villi and unfavourable outcome of pregnancy.
    Author: Simoni G, Brambati B, Maggi F, Jackson L.
    Journal: Ann Genet; 1992; 35(2):110-2. PubMed ID: 1524407.
    Abstract:
    Two cases of trisomy 16 confined to placental tissue associated with an unfavourable outcome of the pregnancy are reported. In the first case, after a diagnosis of an apparent non-mosaic trisomy 16 at chorionic villi sample (CVS), an intrauterine fetal death occurred at the 22nd week. In the second case a mosaic with trisomy 16 was found in chorionic villi and the fetus was still-born at 38 weeks. From a comparison of their cases with those of the literature, the authors conclude that a trisomy 16 confined to placental tissue has a negative effect on fetal growth and pregnancy outcome.
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