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  • Title: Scaling of microtubule force-velocity curves obtained at different tubulin concentrations.
    Author: Janson ME, Dogterom M.
    Journal: Phys Rev Lett; 2004 Jun 18; 92(24):248101. PubMed ID: 15245135.
    Abstract:
    We present a single curve that describes the decay in average growth velocity for microtubules in response to a mechanical force. Curves obtained at two new and one previously studied tubulin concentrations coalesce when normalized with the growth velocity at zero load. This scaling provides direct evidence for a force-independent molecular off rate, in agreement with Brownian ratchet models. In addition, microtubule length changes were measured with a precision up to 10 nm, revealing that microtubules under load abruptly switch between different growth velocities.
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