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  • Title: Mycobacterium leprae-induced demyelination: a model for early nerve degeneration.
    Author: Rambukkana A.
    Journal: Curr Opin Immunol; 2004 Aug; 16(4):511-8. PubMed ID: 15245748.
    Abstract:
    The molecular events that occur at the early phase of many demyelinating neurodegenerative diseases are unknown. A recent demonstration of rapid demyelination and axonal injury induced by Mycobacterium leprae provides a model for elucidating the molecular events of early nerve degeneration which might be common to neurodegenerative diseases of both infectious origin and unknown etiology. The identification of the M. leprae-targeted Schwann cell receptor, dystroglycan, and its associated molecules in myelination, demyelination and axonal functions suggests a role for these molecules in early nerve degeneration.
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