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  • Title: Psychopathological traits and 5-HT2A receptor promoter polymorphism (-1438 G/A) in patients suffering from Anorexia Nervosa and Bulimia Nervosa.
    Author: Ricca V, Nacmias B, Boldrini M, Cellini E, di Bernardo M, Ravaldi C, Tedde A, Bagnoli S, Placidi GF, Rotella CM, Sorbi S.
    Journal: Neurosci Lett; 2004 Jul 22; 365(2):92-6. PubMed ID: 15245785.
    Abstract:
    Various studies have evaluated the possible role of the -1438G/A polymorphism within the 5-HT2A receptor gene in the susceptibility to Eating Disorders (EDs). One hundred and forty-eight ED patients (EDp) and 89 control subjects were interviewed by means of the Eating Disorder Examination (EDE) and analyzed for distribution of the -1438G/A polymorphism. Patients with the AA genotype suffering from Anorexia Nervosa and Bulimia Nervosa showed higher Weight and Shape Concern (P = 0.003 and P = 0.010, respectively) scores and greater overall severity of the ED psychopathology (EDE total score) (P = 0.012). The obtained preliminary data suggest the use of dimensional psychopathological measures in ED genetic studies.
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