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  • Title: Cytochrome oxidase activity in hippocampal synaptic mitochondria during aging: a quantitative cytochemical investigation.
    Author: Bertoni-Freddari C, Fattoretti P, Giorgetti B, Solazzi M, Balietti M, Casoli T, Di Stefano G.
    Journal: Ann N Y Acad Sci; 2004 Jun; 1019():33-6. PubMed ID: 15246989.
    Abstract:
    Synaptic mitochondria, cytochemically positive to cytochrome oxidase (COX) activity, were investigated by morphometric methods in the hippocampal dentate gyrus of adult and old rats. The number of mitochondria/microm(3) of tissue (Nv), the volume fraction occupied by mitochondria/microm(3) of tissue (Vv), the average mitochondrial volume (V), the longer mitochondrial diameter (F(max)), and the ratio R:mitochondrial area/overall area of the cytochemical precipitate due to COX activity were measured on COX-positive organelles. In old animals, Nv, Vv, V, and F(max) increased at a not significant extent; R was not significantly decreased. The complement (%) of longer organelles was higher in old animals. COX activity is currently considered an endogenous marker of neuronal oxidative metabolism; thus, although our findings refer to the discrete subpopulation of COX-positive organelles located at synaptic terminals, they support that changes of mitochondrial ultrastructure and metabolic competence may contribute to the age-related alterations of neuronal performances.
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