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  • Title: Antiplaque efficacy of a triclosan/copolymer prebrush rinse: a plaque prevention clinical study.
    Author: Deasy MJ, Gattista G, Rustogi KN, Volpe AR.
    Journal: Am J Dent; 1992 Apr; 5(2):91-4. PubMed ID: 1524754.
    Abstract:
    A 5-day, double-blind parallel clinical study was conducted to determine the antiplaque efficacy of a pre-brush rinse containing 0.03% triclosan and 0.125% of a copolymer of polyvinyl methyl ether maleic acid as compared to a matching matching placebo pre-brush rinse. A total of 114 subjects were stratified into two balanced groups according to baseline Quigley-Hein Plaque Index scores. Each group was randomly assigned to use either the triclosan/copolymer pre-brush rinse or the placebo pre-brush rinse. All subjects received a thorough oral prophylaxis at the start of the study. They rinsed their mouths twice daily (mornings and evenings) for 1 minute with 15 cc of their assigned pre-brush rinse. Immediately after rinsing, subjects brushed their teeth for 30 seconds with a commercially-available dentifrice containing 0.76% sodium monofluorophosphate and a soft-bristled toothbrush. The morning rinsing/brushing procedure was done under supervision at the clinical facility. The evening rinsing/brushing procedure was done at home. After 5 days' use of their assigned pre-brush rinse, subjects were evaluated for plaque formation using the modified Quigley-Hein Plaque Index scoring system. As compared to the matching placebo pre-brush rinse, the results showed: 1) The triclosan/copolymer pre-brush rinse provided a 28.15% reduction in plaque formation on all surfaces of the teeth. This reduction was statistically significant (P less than 0.001); 2) The triclosan/copolymer pre-brush rinse provided a 50% reduction in plaque formation on the "more difficult to brush" surfaces of the teeth.(ABSTRACT TRUNCATED AT 250 WORDS)
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