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  • Title: The streptococcolytic enzyme zoocin A is a penicillin-binding protein.
    Author: Heath LS, Heath HE, LeBlanc PA, Smithberg SR, Dufour M, Simmonds RS, Sloan GL.
    Journal: FEMS Microbiol Lett; 2004 Jul 15; 236(2):205-11. PubMed ID: 15251198.
    Abstract:
    Zoocin A is a streptococcolytic enzyme produced by Streptococcus equi subsp. zooepidemicus 4881 that has an unknown site of action on the peptidoglycans of susceptible organisms. Analysis of a mutant strain in which the genes for zoocin A and resistance to zoocin A were inactivated revealed that this strain was more susceptible to beta-lactam antibiotics than the parental organism. Purified zoocin A had weak beta-lactamase activity, bound radioactive penicillin covalently, and its streptococcolytic activity was inhibited by penicillin. Thus, zoocin A is a penicillin-binding protein and presumably is a D-alanyl endopeptidase.
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