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  • Title: New total synthesis of the marine antitumor alkaloid (-)-agelastatin A.
    Author: Domostoj MM, Irving E, Scheinmann F, Hale KJ.
    Journal: Org Lett; 2004 Jul 22; 6(15):2615-8. PubMed ID: 15255704.
    Abstract:
    [reaction: see text] A new total synthesis of (-)-agelastatin A (1) has been achieved from the chiral oxazolidinone (-)-3. Although enone transposition was problematic when the Michael ring closure of 2 was attempted with strong base, the desired cyclization could be effected with Hunig's base after the pyrrole nucleus was brominated. Subsequent reduction and monobromination afforded synthetic (-)-agelastatin A (1).
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