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  • Title: [Effects of lithium on primary cultured cerebrocortical neurons of rat].
    Author: Yang F, Li JS, Yang F.
    Journal: Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi; 2004 Jun; 22(3):188-90. PubMed ID: 15256152.
    Abstract:
    OBJECTIVE: To explore the neuroprotection and the impact on brain development of lithium, the effects of lithium salt on the growth and survival of primary cultured cerebrocortical neurons were studied. METHODS: The technique of primary cultured cerebrocortical neurons of newborn rats with serum-free medium was established, and the growth and survival of neurons treated with different doses of lithium chloride (0.625, 1.250, 2.500, 5.000, 10.000 mmol/L) were observed. The length of neuronal synapse, cell viability by MTT reduction assay were also measured. RESULTS: The neurons were brighter, germinated rapidly, the neuronal synapse lengthened markedly, and the neurons viability was also better after treated with lithium chloride. Among the five doses, 5.000 mmol/L had the best effect [(53.80 +/- 5.84) micro m, P < 0.01]. CONCLUSION: Lithium chloride can promote the growth and survival of neurons.
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