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  • Title: [Three-dimensional architecture and ultrastructure of the cerebral microvasculature of missile brain wound in cats].
    Author: Qian C, Chen CC.
    Journal: Di Yi Jun Yi Da Xue Xue Bao; 2004 Jul; 24(7):765-7. PubMed ID: 15257897.
    Abstract:
    OBJECTIVE: To explore the changes of cerebral microvasculature in cats with missile brain wound. METHODS: The microvascular corrosion casts of the brain were examined by scanning electron microscopy, and the ultra-thin slices of the brain were inspected by transmission electron microscopy. RESULTS: The brain microvasculature showed evidently abnormal morphological changes, with both vasospasm and vasodilation as well as concurrent bleeding and ischemia. Strong pathological contraction of vascular sphincter, rupture of some microvessels, and increased microvilli and vacuoles in the endothelial cells were observed. Loosening of the intercellular tight junction and basal membrane rupture occurred along with perivascular swelling and neural cell damages. CONCLUSION: Morphological or functional changes occur in the cerebral microvasculature leading to secondary brain injury after missile brain wound in cats.
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