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  • Title: Benzodiazepine inhibitors of the MMPs and TACE. Part 2.
    Author: Levin JI, Nelson FC, Delos Santos E, Du MT, MacEwan G, Chen JM, Ayral-Kaloustian S, Xu J, Jin G, Cummons T, Barone D.
    Journal: Bioorg Med Chem Lett; 2004 Aug 16; 14(16):4147-51. PubMed ID: 15261259.
    Abstract:
    A series of benzodiazepine MMP/TACE inhibitors bearing polar moieties has been synthesized in an effort to optimize inhibitory activity against LPS-stimulated TNF production in human monocytes and oral activity in a murine LPS model.
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