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  • Title: Synthesis and QSAR studies of pyrimido[4,5-d]pyrimidine-2,5-dione derivatives as potential antimicrobial agents.
    Author: Sharma P, Rane N, Gurram VK.
    Journal: Bioorg Med Chem Lett; 2004 Aug 16; 14(16):4185-90. PubMed ID: 15261267.
    Abstract:
    A number of pyrimido[4,5-d]pyrimidine-2,5-dione derivatives were synthesized and screened for antibacterial and antifungal activities. All the synthesized compounds showed the potent antimicrobial activity. The quantitative structure-activity relationship investigation was applied to find a correlation between the different physicochemical parameters of the compounds studied and their biological activity.
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