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  • Title: P4 cap modified tetrapeptidyl alpha-ketoamides as potent HCV NS3 protease inhibitors.
    Author: Sun DX, Liu L, Heinz B, Kolykhalov A, Lamar J, Johnson RB, Wang QM, Yip Y, Chen SH.
    Journal: Bioorg Med Chem Lett; 2004 Aug 16; 14(16):4333-8. PubMed ID: 15261297.
    Abstract:
    We describe herein the design, syntheses, and biological evaluation of new series of P4 tetrazole and adipic acid, ester, amide capped tetrapeptidyl alpha-ketoamide based HCV protease inhibitors.
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