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  • Title: Correlation of neuron-specific enolase and S100B with histological cerebral damage in fetal sheep after severe asphyxia.
    Author: Fujii EY, Kozuki M, Mu J, Ino Y, Ushioda N, Tomimatsu T, Fukuda H, Kanzaki T, Nakayama M, Murata Y.
    Journal: Brain Res; 2004 Aug 20; 1018(1):136-40. PubMed ID: 15262215.
    Abstract:
    Experimental brain damage was induced in 16 fetal sheep by umbilical cord occlusion, and the correlation of neuron-specific enolase (NSE) or S100B with the damage grade was investigated in seven fetuses. Significant correlations of damage degree with NSE (p = 0.016) and S100B (p = 0.018) in serum 2 h after insult were shown by Spearman's test. These findings suggest that they represent potentially useful markers for detecting brain damage at early stage after ischemic insult.
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