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Title: Chronic lymphocytic leukemia in the course of chronic myelocytic leukemia: evidence of independent clonal origin as shown by interphase fluorescence in situ hybridization and fluorescence-activated cell sorting. Author: Chang H, Sutherland R, Nayar R, Li D, Kamel-Reid S, Mile MA, Messner H, Lipton J. Journal: Cancer Genet Cytogenet; 2004 Jul 15; 152(2):146-8. PubMed ID: 15262435. Abstract: We report the case of a 57-year-old man who developed chronic lymphocytic leukemia (CLL) several months after the initial diagnosis of Philadelphia (Ph) chromosome-positive (Ph(+)) chronic myelocytic leukemia. CLL cells were purified by using fluorescence-activated cell sorting and further analyzed using interphase fluorescence in situ hybridization with probes to detect the BCR/ABL fusion gene. We provide evidence that the CLL cells arose in a Ph(-) clone.[Abstract] [Full Text] [Related] [New Search]