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  • Title: Imipenem resistance in Enterobacter aerogenes is associated with derepression of chromosomal cephalosporinases and impaired permeability.
    Author: Tzouvelekis LS, Tzelepi E, Mentis AF, Vatopoulos AC, Tsakris A.
    Journal: FEMS Microbiol Lett; 1992 Aug 15; 74(2-3):195-9. PubMed ID: 1526451.
    Abstract:
    Enterobacter aerogenes mutants with high-level resistance to imipenem were studied. They were derived from strains characterized by stable over-production of a class-I beta-lactamase. This enzyme (pI = 8.2) exhibited high affinity toward imipenem and hydrolysed the drug slowly. Imipenem-resistant mutants lacked a major 43-kDa outer membrane protein and displayed decreased permeability to cephaloridine. Introduction of a plasmid coding for the regulatory ampD gene abolished beta-lactamase production and rendered the mutants susceptible to imipenem.
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