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  • Title: [Leydig cell tumor presenting as precocious pseudopuberty in a 4-year-old boy].
    Author: Alonso Domínguez FJ, Osorio Acosta VA.
    Journal: Arch Esp Urol; 2004 May; 57(4):426-8. PubMed ID: 15270286.
    Abstract:
    OBJECTIVES: To report one case of isosexual precocious pseudopuberty in a 4-year-old boy caused by an interstitial cell testicular tumor. METHODS: Physical exam, blood tests, hormonal determinations, adrenal suppression tests, bone age, orchiectomy and pathologic study of the specimen were performed. RESULTS: Physical examination showed a boy with muscle development, acne; body, sexual and face hair corresponding to an older boy; with increased volume of the left testicle and infantile contralateral testicle. Urinary 17-ketosteroids were elevated and did not decrease after dexametasone. Bone age corresponded to an 11-year-old standard. Pathologic study showed an interstitial cell tumor. Puberty changes disappeared after orchiectomy. CONCLUSIONS: This diagnosis should be taken into consideration in every case of accelerated sexual development in a boy with testicular tumor and without maturation of the contralateral testicle.
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