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  • Title: New cytotoxic oleanane-type triterpenoids from the cones of Liquidamber styraciflua.
    Author: Sakai K, Fukuda Y, Matsunaga S, Tanaka R, Yamori T.
    Journal: J Nat Prod; 2004 Jul; 67(7):1088-93. PubMed ID: 15270558.
    Abstract:
    Two new oleanane-type triterpenoids (1 and 2), together with two known compounds, 6beta-hydroxy-3-oxo-lup-20(29)-en-28-oic acid (3) and 3,11-dioxoolean-12-en-28-oic acid (4), were isolated from the stem bark of Liquidamber styraciflua. The structures of 1 and 2 were determined to be 25-acetoxy-3alpha-hydroxyolean-12-en-28-oic acid (1) and 3alpha,25-dihydroxyolean-12-en-28-oic acid (2) on the basis of spectroscopic methods and chemical conversion. Compound 1 showed strong cytotoxicity against a disease-oriented panel of 39 human cancer cell lines, although compounds 2, 3, and 4 showed weaker activity compared to 1.
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