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  • Title: Cyclic peptides from a Ruegeria strain of bacteria associated with the sponge Suberites domuncula.
    Author: Mitova M, Popov S, De Rosa S.
    Journal: J Nat Prod; 2004 Jul; 67(7):1178-81. PubMed ID: 15270577.
    Abstract:
    Two new cyclic peptides, cyclo-(glycyl-L-seryl-L-prolyl-L-glutamyl) and cyclo-(glycyl-L-prolyl-L-glutamyl), have been isolated from the cell extract of a Ruegeria strain associated with cell cultures of Suberites domuncula. Three other cyclopeptides have been isolated for the first time from a natural source. Additionally, a new diastereoisomer of a known compound is reported. The structures of isolated compounds have been elucidated by means of spectroscopic data (1D-, 2D-NMR, HRESIMS) and chiral HPLC analysis. The new cyclopeptides exhibited moderate antimicrobial activity against Bacillus subtilis.
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