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  • Title: TRICOM: enhanced vaccines as anticancer therapy.
    Author: Levy B, Panicalli D, Marshall J.
    Journal: Expert Rev Vaccines; 2004 Aug; 3(4):397-402. PubMed ID: 15270644.
    Abstract:
    Renewed interest in immune therapies for the treatment of cancer has sparked a number of different immune stimulation approaches. These include antibody based, dendritic cell-based and vaccine-based therapies. The poxvirus-based vaccines incorporating a TRIad of COstimulatory Molecules (TRICOM) will be reviewed here. Through stimulation of cancer-specific T-cell responses, researchers have demonstrated interesting clinical efficacy in addition to the high safety profile in clinical trials.
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