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  • Title: Clonidine in respiratory panic disorder subtype.
    Author: Valença AM, Nardi AE, Mezzasalma MA, Nascimento I, Lopes FL, Zin WA, Versiani M.
    Journal: Arq Neuropsiquiatr; 2004 Jun; 62(2B):396-8. PubMed ID: 15273833.
    Abstract:
    OBJECTIVE: Clonidine, which inhibits locus coeruleus discharge, would seem for theoretical reasons to be a good antipanic drug. Panic disorder (PD) presents a heterogeneous cluster of symptoms and a classification based on subtypes has been suggested and the respiratory symptoms group appears as a distinct subtype. METHOD: We report three cases of respiratory PD patients who were successfully treated with clonidine. RESULTS: Patients obtained panic free status, reduced anxiety levels and better functioning after clonidine administration (0.30-0.45 mg/day) for 6 weeks. CONCLUSION: Clonidine can be effective in the treatment of respiratory PD. This drug might play a role in relieving symptoms of anxiety due to noradrenergic hyperactivity in these patients.
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