These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Indomethacin attenuates hyperthermia produced by anterior coronal lateral hypothalamic knife cuts.
    Author: Rau V, Grijalva CV.
    Journal: Brain Res Bull; 2004 Jul 30; 64(1):53-8. PubMed ID: 15275957.
    Abstract:
    Electrolytic lesions of the lateral hypothalamus (LH) and coronal knife cuts of fibers anterior to the LH produce an elevation in core body temperature, or hyperthermia. Prostaglandin has been shown to mediate hyperthermia produced by electrolytic LH lesions. The present study characterizes the time course and the role of prostaglandin in mediating knife-cut-induced hyperthermia. Results show that the prostaglandin synthesis inhibitor indomethacin significantly attenuates hyperthermia produced by the knife cuts, suggesting that prostaglandin is involved in mediating this temperature increase. A disruption of axonal fibers that project from the LH to the preoptic area is postulated to be responsible for the temperature increase. There was no effect of knife cuts on food intake and body weight loss, which were also measured, suggesting that this fiber system is not involved in feeding behavior.
    [Abstract] [Full Text] [Related] [New Search]