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  • Title: First and second generations of COX-2 selective inhibitors.
    Author: de Leval X, Julémont F, Benoit V, Frederich M, Pirotte B, Dogné JM.
    Journal: Mini Rev Med Chem; 2004 Aug; 4(6):597-601. PubMed ID: 15279593.
    Abstract:
    The identification and characterization of the inducible form of cyclooxygenases (COX-2) stimulated the investigations to develop efficient, non-steroidal anti-inflammatory drugs (NSAIDs) with reduced side effects (essentially gastro-intestinal toxicity) compared to classical NSAIDs. This review focuses on the chemical and pharmacological properties (pre-clinical data) of marketed COX-2 inhibitors.
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