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  • Title: Aqueous penetration of gatifloxacin and levofloxacin into the rabbit aqueous humor following topical dosing.
    Author: Levine JM, Noecker RJ, Lane LC, Snyder RW, Rapedius M, Blanchard J.
    Journal: J Ocul Pharmacol Ther; 2004 Jun; 20(3):210-6. PubMed ID: 15279726.
    Abstract:
    The aqueous penetration of the commercial preparations of the fluoroquinolone antibiotics ofloxacin, ciprofloxacin, levofloxacin, and gatifloxacin were compared following topical dosing in a rabbit model. Levofloxacin achieved the highest aqueous concentrations, with a mean aqueous level of 4.8014 microcg/mL (p = 0.002, p = 0.00002, p = 0.015.) Ofloxacin (2.5136 microcg/mL) and gatifloxacin (2.4817 microcg/mL) achieved statistically equal aqueous concentrations (p = 0.479). Ciprofloxacin reached the lowest levels in the aqueous humor (0.9616 microcg/mL, p = 0.00002, 0.00004, 0.008). Gatifloxacin alone achieved concentrations in excess of the MIC90s of gram-positive pathogens of concern.
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