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  • Title: Azelaic and pimelic acids: metabolic intermediates or artefacts?
    Author: Bennett MJ, Ragni MC, Hood I, Hale DE.
    Journal: J Inherit Metab Dis; 1992; 15(2):220-3. PubMed ID: 1527989.
    Abstract:
    Azelaic and pimelic acids are excreted in elevated amounts in urine in disorders of mitochondrial beta-oxidation and disorders of peroxisomal beta-oxidation, for which they are of significant diagnostic value. We have detected the presence of azelaic, pimelic and even-chain-length dicarboxylic acids (adipic, suberic and sebacic acids) arising artefactually as a result of storage of small sample volumes in plastic containers. Storage of samples for organic acid analysis in glass containers is recommended.
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