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  • Title: A powerful selection assay for mixture libraries of DNA alkylating agents.
    Author: Ham YW, Boger DL.
    Journal: J Am Chem Soc; 2004 Aug 04; 126(30):9194-5. PubMed ID: 15281804.
    Abstract:
    A simple and powerful selection assay that permits the separation (rpHPLC), quantitation (ELSD), and identification (ESI-MS) of thermally released adenine adducts derived from duocarmycin analogues is detailed that can establish the most effective DNA alkylating agents in synthetic combinatorial mixtures.
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