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  • Title: [Activity of Centella asiatica in venous insufficiency].
    Author: Cesarone MR, Laurora G, De Sanctis MT, Belcaro G.
    Journal: Minerva Cardioangiol; 1992 Apr; 40(4):137-43. PubMed ID: 1528498.
    Abstract:
    In this a review concerning TTFCA, its effects on metabolism in the connective tissue of the vascular wall and on the microcirculation are presented and discussed. This compound is effective in venous insufficiency, reducing ankle edema, foot swelling, capillary filtration rate and by improving microcirculatory parameters (RF, VAR PO2-PCO2). TTFCA displays a significant activity in venous hypertensive microangiopathy and its effects are dose-dependent.
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