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  • Title: Theoretical analysis of dynamic force spectroscopy experiments on ligand-receptor complexes.
    Author: Raible M, Evstigneev M, Reimann P, Bartels FW, Ros R.
    Journal: J Biotechnol; 2004 Aug 26; 112(1-2):13-23. PubMed ID: 15288937.
    Abstract:
    The forced rupture of single chemical bonds in biomolecular compounds (e.g. ligand-receptor systems) as observed in dynamic force spectroscopy experiments is addressed. Under the assumption that the probability of bond rupture depends only on the instantaneously acting force, a data collapse onto a single master curve is predicted. For rupture data obtained experimentally by dynamic AFM force spectroscopy of a ligand-receptor bond between a DNA and a regulatory protein we do not find such a collapse. We conclude that the above mentioned, generally accepted assumption is not satisfied and we discuss possible explanations.
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