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  • Title: Detection and manipulation of biomolecules by magnetic carriers.
    Author: Brzeska M, Panhorst M, Kamp PB, Schotter J, Reiss G, Pühler A, Becker A, Brückl H.
    Journal: J Biotechnol; 2004 Aug 26; 112(1-2):25-33. PubMed ID: 15288938.
    Abstract:
    The detection and manipulation of single molecules on a common platform would be of great interest for basic research of biological or chemical systems. A promising approach is the application of magnetic carriers. The principles are demonstrated in this contribution. It is shown that paramagnetic beads can be detected by highly sensitive magnetoresistive sensors yielding a purely electronic signal. Different configurations are discussed. The capability of the sensors to detect even single markers is demonstrated by a model experiment. In addition, the paramagnetic beads can be used as carriers for biomolecules. They can be manipulated on-chip via currents running through specially designed line patterns. Thus, magnetic markers in combination with magnetoresistive sensors are a promising choice for future integrated lab-on-a-chip systems.
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