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  • Title: [Epstein-Barr virus infection in lymphoepithelial carcinoma of salivary glands in Sichuan Chinese].
    Author: Wu LY, Cheng J, Lu Y, Zhou ZY, Saku T.
    Journal: Sichuan Da Xue Xue Bao Yi Xue Ban; 2004 Jul; 35(4):506-7. PubMed ID: 15291112.
    Abstract:
    OBJECTIVE: To determine the prevalence of Epstein-Barr virus (EBV) infection in lymphoepithelial carcinoma (LEC) of salivary glands in Sichuan Chinese and discuss the role of EBV infection in pathogenesis of LEC. METHODS: Paraffin sections of 16 cases of LEC and 4 cases of benign lymphoepithelial lesion (BLEL) of salivary glands, 4 cases of non-specific chronic sialadenitis were examined by in situ hybridization for EBV encoded small RNA-1 (EBER-1) using 30-base synthesized oligonucleotide probe. RESULTS: Strong signals for EBER-1 were obtained in most of tumor cell nuclei in all the specimens of LEC (16/16); in contrast, there were no significant signals observed in the examination of 4 cases of BLEL and 4 cases of non-specific chronic sialadenitis. CONCLUSION: The results indicate that EBV plays an important role in the pathogenesis of LEC of salivary glands in Sichuan Chinese.
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