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  • Title: [Efficacy of erythropoietin in anemia of patients with immuno-lymphoproliferative disease].
    Author: Longo G, Fiorani C, Bonacorsi G, Vanzanelli P, Sani F, Bevini M, Curci G, Torelli U.
    Journal: Recenti Prog Med; 1992; 83(7-8):449-54. PubMed ID: 1529159.
    Abstract:
    Anemia is a common complication of lymphoproliferative syndromes. The exact pathogenic mechanism of this anemia is unclear. Many patients require progressive and persistent blood transfusions. We treated 10 patients (8 with multiple myeloma, 1 with non Hodgkin Lymphoma, 1 with chronic lymphocytic leukemia) by administering low doses of recombinant human erythropoietin (60 U/kg 3 times a week s.c.). All patients presented anemia with hemoglobin levels less than 10 gr/dl; renal function was not impaired (serum creatinine levels less than 1.2 mg/dl or creatinine clearance greater than 60 ml/min). A response was defined as an increase of hemoglobin level of at least 2 gr/dl or stop of red-cell transfusion within the first 3 months of treatment. Nine patients (90%) responded to treatment with a significant increase in the hemoglobin concentration. Two patients presented a cerebral stroke not correlated with erythropoietin administration.
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