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  • Title: Hypertrophic pulmonary osteoarthropathy: control of pain and symptoms with pamidronate.
    Author: Amital H, Applbaum YH, Vasiliev L, Rubinow A.
    Journal: Clin Rheumatol; 2004 Aug; 23(4):330-2. PubMed ID: 15293094.
    Abstract:
    This case presents a patient with hypertrophic osteoarthropathy of the lower extremities that developed secondary to congenital cyanotic heart disease. The major clinical manifestation was severe bilateral leg pain. The pain that was debilitating in nature completely resolved following a single administration of 60 mg pamidronate. Hypertrophic osteoarthropathy (HOA) is an acquired, uncommon disorder of obscure etiology. It has been described mainly in association with chronic suppurative pulmonary diseases, bronchogenic carcinoma and lung metastases, cystic fibrosis, and cyanotic congenital malformations of the heart.
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