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  • Title: Mechanotransduction and the regulation of protein synthesis in skeletal muscle.
    Author: Hornberger TA, Esser KA.
    Journal: Proc Nutr Soc; 2004 May; 63(2):331-5. PubMed ID: 15294051.
    Abstract:
    Repeated bouts of resistance exercise produce an increase in skeletal muscle mass. The accumulation of protein associated with the growth process results from a net increase in protein synthesis relative to breakdown. While the effect of resistance exercise on muscle mass has long been recognized, the mechanisms underlying the link between high-resistance contractions and the regulation of protein synthesis and breakdown are, to date, poorly understood. In the present paper skeletal muscle will be viewed as a mechanosensitive cell type and the possible mechanisms through which mechanically-induced signalling events lead to changes in rates of protein synthesis will be examined.
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