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  • Title: NPY-(18-36) and pertussis toxin distinguish between the negative and positive contractile effects of neuropeptide Y (NPY) in ventricular cardiomyocytes.
    Author: Millar BC, McDermott BJ, Piper HM, Balasubramaniam A, Weis T.
    Journal: Adv Exp Med Biol; 1992; 311():325-6. PubMed ID: 1529762.
    Abstract:
    The mechanism of action of NPY to produce contractions of adult rat ventricular myocytes was investigated. Positive effects were mediated through an L-type Ca2+ channel. Negative effects, linked through an inhibitory G-protein to a transient outward K+ channel, could be antagonised by NPY-(18-36).
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