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  • Title: Ovulation induction and successful pregnancy outcome in two patients with Prop1 gene mutations.
    Author: Voutetakis A, Sertedaki A, Livadas S, Maniati-Christidi M, Mademtzis I, Bossis I, Dacou-Voutetakis C, Messinis IE.
    Journal: Fertil Steril; 2004 Aug; 82(2):454-7. PubMed ID: 15302300.
    Abstract:
    OBJECTIVE: To describe ovulation induction and pregnancy outcome in a unique model of genetically determined combined pituitary hormone deficiency (CPHD), with respect to the necessity for GH substitution therapy. DESIGN: Case report. SETTING: Academic units. PATIENT(S): Two patients with childhood onset of CPHD (GH, PRL, TSH, LH, FSH) caused by a genetic defect (GA296del mutation) of the Prop1 gene. MAIN OUTCOME MEASURE(S): Ovulation, pregnancy outcome, and fetal growth. RESULT(S): Successful pregnancy outcome and delivery of normal, full-term newborns were achieved in both patients with the use of gonadotropins and L-T(4). Growth hormone supplementation was not necessary. No lactation was observed. CONCLUSION(S): Patients with Prop1 gene mutations constitute a unique model for studying the role of GH and PRL in ovulation, pregnancy, and fetal growth. Our data indicate that for women with CPHD, ovulation and pregnancy are possible with a classic regimen for hypogonadotropic hypogonadism, without the need for GH substitution therapy.
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