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  • Title: [Study of DDS to the lymph node-metastases of the gastric cancer by the endoscopic injection of Lip-ADM].
    Author: Hirahata S, Kumai K, Ishibiki K, Kitajima M.
    Journal: Gan To Kagaku Ryoho; 1992 Aug; 19(10 Suppl):1591-4. PubMed ID: 1530313.
    Abstract:
    We studied the drug delivery and anti-tumor effect of the endoscopic injection of liposomal adriamycin (Lip-ADM) in the submucosa of stomach by rabbit model. Concerning the drug delivery to regional lymphnode, the lymphnode ADM concentration of Lip-ADM injection group was higher than that of free ADM group (p less than 0.05). We also studied the lymphnodes pathohistologically. The lymphnodes of the rabbits injected with Lip-ADM indicated massive necrosis, whereas those of the rabbits injected with free ADM indicated residual tumor. Among clinical cases, patients injected Lip-ADM had paraaortic lymphnodes in which the adriamycin remained 10 days. The endoscopic injection of Lip-ADM into the submucosa of the stomach appeared to be an effective drug delivery system.
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