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  • Title: Ligands of the peroxisome proliferator-activated receptor-gamma and heart failure.
    Author: Thiemermann C.
    Journal: Br J Pharmacol; 2004 Jul; 142(6):1049-51. PubMed ID: 15303252.
    Abstract:
    Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors that are related to retinoid, steroid and thyroid hormone receptors. The PPAR subfamily comprises of three members, PPAR-alpha, PPAR-beta and PPAR-gamma. There is good evidence that ligands of PPAR-gamma, including certain thiazolinediones, reduce myocardial tissue injury and infarct size. The use of PPAR-gamma agonists in the treatment of heart failure is, however, controversial.
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