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  • Title: [Preoperative administration of 5-FU emulsion for lymph nodes metastasis of pancreatic carcinoma].
    Author: Kakizaki K, Yamada Y, Yamauchi H.
    Journal: Gan To Kagaku Ryoho; 1992 Aug; 19(10 Suppl):1679-81. PubMed ID: 1530330.
    Abstract:
    5-FU oil emulsion (n = 5) or 5-FU dry syrup (n = 4), at a daily dose of 332mg for 7 days, was administered preoperatively to patient with periampullary carcinoma to evaluate the uptake of 5-FU to regional lymph nodes. In the group given 5-FU oil emulsion, the mean concentration of 5-FU was 293 +/- 97 ng/ml (mean +/- S.E.D), and that of the group given dry syrup was 72 +/- 20 ng/ml. Although no statistically significant difference was found, 5-FU seemed to reach the regional lymph nodes as an emulsion rather than as an aqueous solution. Preoperative administration of 5-FU emulsion might have some favorable effect on lymph node metastasis and lymph invasion of pancreatic carcinoma.
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