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  • Title: Hydroxylation of HIF-1: oxygen sensing at the molecular level.
    Author: Semenza GL.
    Journal: Physiology (Bethesda); 2004 Aug; 19():176-82. PubMed ID: 15304631.
    Abstract:
    The ability to sense and respond to changes in oxygenation represents a fundamental property of all metazoan cells. The discovery of the transcription factor HIF-1 has led to the identification of protein hydroxylation as a mechanism by which changes in PO2 are transduced to effect changes in gene expression.
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