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  • Title: Tris(trimethylsilyl)silane: an unprecedented enhancement in the diastereoselectivity of radical cyclisations to give 2,4-disubstituted piperidines.
    Author: Gandon LA, Russell AG, Snaith JS.
    Journal: Org Biomol Chem; 2004 Aug 21; 2(16):2270-1. PubMed ID: 15305204.
    Abstract:
    Cyclisation of bromides 4a-f mediated by tributyltin hydride affords predominantly the trans piperidines 5a-f with modest diastereomeric ratios, while cyclisation with tris(trimethylsilyl)silane affords the same products with diastereomeric ratios of up to 99 : 1.
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