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  • Title: Creation of a transgenic mouse for hair-cell gene targeting by using a modified bacterial artificial chromosome containing Prestin.
    Author: Tian Y, Li M, Fritzsch B, Zuo J.
    Journal: Dev Dyn; 2004 Sep; 231(1):199-203. PubMed ID: 15305300.
    Abstract:
    We made a transgenic mouse that expresses Cre recombinase activity in inner ear hair cells by using a modified bacterial artificial chromosome containing Prestin. Cre recombinase activity was restricted to inner and outer hair cells, a subset of vestibular hair cells, spiral and vestibular ganglia in the inner ear, and a subset of cells in the testis, epididymis, and ear bone. This mouse will be useful for hair-cell-specific gene targeting.
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