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  • Title: Molecular characterisation of streptomycin-resistant Mycobacterium tuberculosis strains isolated in Poland.
    Author: Brzostek A, Sajduda A, Sliwiński T, Augustynowicz-Kopeć E, Jaworski A, Zwolska Z, Dziadek J.
    Journal: Int J Tuberc Lung Dis; 2004 Aug; 8(8):1032-5. PubMed ID: 15305490.
    Abstract:
    Primary drug resistance of Mycobacterium tuberculosis strains in Poland increased two-fold between 1997 and 2000. Among 3705 drug-resistant strains investigated in 2000, 169 were resistant to streptomycin alone or in combination with isoniazid, rifampicin and/or ethambutol. The molecular basis of streptomycin resistance for 88 (52%) of these strains in comparison with 15 susceptible controls was determined. The most prevalent mutation was the single substitution Lys43Arg in the rpsL gene, found in 30.7% of the strains analysed. However, as many as 51% of the strains investigated carried no mutation in the rpsL or rrs genes. The multiple mutations present in two Beijing family strains were also identified.
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