These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Atomic force microscopy studies on DNA structural changes induced by vincristine sulfate and aspirin.
    Author: Zhu Y, Zeng H, Xie J, Ba L, Gao X, Lu Z.
    Journal: Microsc Microanal; 2004 Apr; 10(2):286-90. PubMed ID: 15306054.
    Abstract:
    We report that atomic force microscopy (AFM) studies on structural variations of a linear plasmid DNA interact with various concentrations of vincristine sulfate and aspirin. The different binding images show that vincrinstine sulfate binding DNA chains caused some loops and cleavages of the DNA fragments, whereas aspirin interaction caused the width changes and conformational transition of the DNA fragments. Two different DNA structural alternations could be explained by the different mechanisms of the interactions with these two components. Our work indicates that the AFM is a powerful tool in studying the interaction between DNA and small molecules.
    [Abstract] [Full Text] [Related] [New Search]