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  • Title: Frequencies of sickle cell trait and glucose-6-phosphate dehydrogenase deficiency differ in highland and nearby lowland malaria-endemic areas of Kenya.
    Author: Moormann AM, Embury PE, Opondo J, Sumba OP, Ouma JH, Kazura JW, John CC.
    Journal: Trans R Soc Trop Med Hyg; 2003; 97(5):513-4. PubMed ID: 15307413.
    Abstract:
    Sickle cell genotype prevalence was 26% in a malaria-holoendemic lowland area compared with 3% in a highland area of Kenya. The prevalence of glucose-6-phosphate dehydrogenase deficiency was 7% and 1% in holoendemic lowland and highland areas, respectively. Lack of protective polymorphisms may contribute to morbidity and mortality during outbreaks of malaria in the highlands.
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