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  • Title: Hierarchy of responsiveness in vivo and in vitro among T cells expressing distinct Mls-1a-reactive v beta domains.
    Author: Waanders GA, McDonald HR.
    Journal: Eur J Immunol; 1992 Jan; 22(1):291-3. PubMed ID: 1530921.
    Abstract:
    In this report we have compared responses of T cells bearing different T cell receptor (TcR) V beta domains, including V beta 6, 7, 8.1 and 9, to the minor lymphocyte stimulatory locus (Mls-1a). The virtually complete deletion of peripheral T cells using these TcR V beta domains in mice expressing Mls-1a verified their Mls-1a reactivity. However, varied responses among these cells following stimulation with Mls-1a in vitro suggested a hierarchy of TcR reactivities for Mls-1a with V beta 6 and V beta 9 greater than V beta 8.1 much greater than V beta 7. This hierarchy was further supported by in vivo studies which showed that V beta 6+CD4+ cells dominated responses to Mls-1a.
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